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Women health :Information on Menopause and Hormone replacement therapy - description medicationMenopause is the irreversible cessation of the female reproductive cycle and menses, which follows from a permanent loss of ovarian response to gonadotropins. This change generally occurs spontaneously between the ages of 45 and 55 in American women, with an average age of 51. Destruction or cessation of function of the ovary prior to age 40 is referred to as premature menopause. Simple hysterectomy terminates menstrual bleeding, but not ovarian function, and thus does not constitute a true menopause. Although it has long been known that the menopausal ovary is nearly depleted of primary follicles, the hormonal events of the perimeno-pausal transition have still not been completely elucidated. Cyclic bleeding ceases, and FSH and LH levels become greatly elevated in serum and urine. Usually the FSH increase is greater. The few remaining follicles do not respond to gonadotropin. Estradiol levels become extremely low (10 to 25 pg/ML), and adrenal estrone becomes the major circulating estrogen. Adipose tissue also provides estrogen.  Women health: female hormones, menopause; clomid description medication
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